what is the purposes of a pancreatic juice

Identification of tobacco-derived compounds in human pancreatic juice. Elevated levels of circulating miR-205, miR-210, miR-492, and miR-1247 in pancreatic juice are, therefore, promising candidate biomarkers of disease and poor prognosis in patients with PDAC. Higher contents of miR-205 and miR-210 were also associated with lymph node metastasis. Enrichment of the four miRNAs in pancreatic juice was associated with decreased OS, as was the combination of miR-205 and miR-210. Inclusion of serum CA19-9 level increased the sensitivity to 91% and the specificity to 100%. Elevated levels of the four miRNAs together predicted PDAC with a specificity of 88% and sensitivity of 87%. A marked difference in the profiles of four circulating miRNAs (miR-205, miR-210, miR-492, and miR-1427) was observed in pancreatic juice collected from patients with PDAC and those without pancreatic disease. Differentially circulating miRNAs were subsequently validated in 88 pancreatic juice samples from 50 PDAC, 19 chronic pancreatitis (CP) patients and 19 NPNH controls.

This study performed profiling of microRNAs (miRNAs) in exocrine pancreatic secretions ( pancreatic juice) by microarray analysis utilizing pancreatic juice from 6 pancreatic ductal adenocarcinoma (PDAC) patients and two pooled samples from 6 non- pancreatic, non-healthy (NPNH) as controls. Wang, Jing Sen, Subrataĭevelopment of sensitive and specific biomarkers, preferably those circulating in body fluids is critical for early diagnosis of cancer. Wang, Jin Raimondo, Massimo Guha, Sushovan Chen, Jinyun Diao, Lixia Dong, Xiaoqun Wallace, Michael B. Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer

What is the purposes of a pancreatic juice